#2524 RESOLVIN D1 ATTENUATES SEPSIS INDUCED ACUTE KIDNEY INJURY TARGETING MITOCHONDRIA AND NF-κB SIGNALING PATHWAY

Abstract Background and Aims Acute kidney injury is a highly common multifactorial renal disease resulting in significant morbidity mortality, especially sepsis-induced acute injury. There no effective therapy available to treat or prevent One of the specialized pro-resolving mediators, Resolvin D1 exhibits special anti-inflammatory effects several inflammatory models, but there little evidence about effect mechanism To explore protective role RvD1 SI-AKI further inherent pathophysiological mechanism, mitochondrial function NF-κB signaling pathway, vitro vivo experiments were conducted. Method We conducted In vitro, human proximal tubular epithelial cells used test apoptosis ratio, cell viability reactive oxygen species level. vivo, C57BL/6 mice injected with lipopolysaccharide establish model. Renal structure, ratio cells, structure related protein gene levels assessed. Results resolvin D1-treated group showed higher lower ratios than LPS group. can not only improve also reduce while mediating dynamics inhibiting pathway. Conclusion has good renoprotective by maintaining This provides an important basis for us develop clinical therapeutic value sepsis.